Lin, Y., Schuurbiers, E., Van, der, V, and de Deckere, E. A. Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. 3-30-2007;268(1-2):50-58. Malpuech-Brugere, C., Verboeket-van de Venne WP, Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Saebo, A., Lassel, T. S., Chardigny, J. M., Sebedio, J. L., and Beaufrere, B. Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans. View abstract. Some early research suggests that taking conjugated linoleic acid daily might cause small improvements in the ability to recall words in older men, but not women. Found in Beef and Dairy — Particularly From Grass-Fed Animals, Large Doses May Cause Serious Side Effects. View abstract. Banni S, Angioni E, Casu V, et al. 2012;11(2):265-7. Anticancer Res 1992;12(6B):2143-2145. Steck, S. E., Chalecki, A. M., Miller, P., Conway, J., Austin, G. L., Hardin, J. W., Albright, C. D., and Thuillier, P. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. Matsuda, M. and DeFronzo, R. A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Nagao, K., Inoue, N., Wang, Y. M., Shirouchi, B., and Yanagita, T. Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. Br.J Nutr 2008;100(1):112-119. View abstract. Bonet, S. B., Quintanar, R. A., Viana, A. M., Iglesias-Gutierrez, E., and Varela-Moreiras, G. The effects of yogurt with isomer enriched conjugated linoleic acid on insulin resistance in obese adolescents. Rossary, A., Arab, K., and Steghens, J. P. Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts. Eur J Clin Nutr 2003;57(4):595-603. The biological activity of CLA was first discovered by researchers who noted that it could help fight cancer in mice (14). Comp Med 2007;57(4):377-382. The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. View abstract. Br J Nutr 2003;90(4):743-750. Sluijs, I., Plantinga, Y., de Roos, B., Mennen, L. I., and Bots, M. L. Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. Most people already ingest some CLA through their diet. (Silver.Spring) 2008;16(5):1019-1024. Visonneau, S., Cesano, A., Tepper, S. A., Scimeca, J. Am.J Clin.Nutr 2010;91(5):1157-1164. Conjugated linoleic acid (CLA) is a fatty acid found in meat and dairy that is believed to have various health benefits (1). Prostaglandins Leukot.Essent.Fatty Acids 2004;71(5):295-301. (Lond) 2007;31(7):1148-1154. View abstract. J Nutr 2006;136(4):992-997. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). View abstract. Conjugated linoleic acid (CLA), body fat, and apoptosis. The effects of conjugated linoleic acid supplementation during resistance training. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J Int Med Res 2001;29:392-6.. View abstract. Anticancer Res 1998;18:1429-34. Int J Obes Relat Metab Disord 2003;27(7):840-847. J Nutr 2009;139(7):1347-1352. For high blood pressure: conjugated linoleic acid 4.5 grams per day along with ramipril (Altace) 37.5 mg/day has been used for 8 weeks. J Bone Miner.Res 1999;14(7):1153-1162. Nutr Cancer 2000;38:151-7. Sneddon, A. Nakamura, Y. K. and Omaye, S. T. Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. It’s one of the magic ingredients that make grass-fed butter and meat so incredible for boosting your physical performance. Stringer, D. M., Zahradka, P., Declercq, V. C., Ryz, N. R., Diakiw, R., Burr, L. L., Xie, X., and Taylor, C. G. Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. View abstract. Alibin, C. P., Kopilas, M. A., and Anderson, H. D. Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma. J Clin.Endocrinol.Metab 2001;86(10):4776-4781. 2010;115(1):123-130. Am.J Clin.Nutr 2007;85(5):1203-1211. However, some human studies using reasonable doses indicate that CLA supplements may cause several mild or moderate side effects, including diarrhea, insulin resistance and oxidative stress (40). I made sure my CLA Supplement was delivered in a super high-quality encapsulation and delivery system. View abstract. The FDA allows CLA to be added to foods and gives it a GRAS (generally regarded as safe) status. Am J Physiol Gastrointest.Liver Physiol 2003;284(6):G996-1005. Lipids 2000;35(10):1065-1071. Cornish, S. M., Candow, D. G., Jantz, N. T., Chilibeck, P. D., Little, J. P., Forbes, S., Abeysekara, S., and Zello, G. A. Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. Additionally, studies in countries where cows predominantly eat grass — rather than grain — show that people with the most CLA in their bodies have a lower risk of heart disease (34). View abstract. Kloss, R., Linscheid, J., Johnson, A., Lawson, B., Edwards, K., Linder, T., Stocker, K., Petitte, J., and Kern, M. Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat. Many studies show that people who eat the most CLA have improved metabolic health and a lower risk of many diseases. Keep in mind that the CLA you find in supplements is not derived from natural foods but made by chemically altering linoleic acid found in vegetable oils (11). View abstract. Matin S, Nemati A, Ghobadi H, Alipanah-Moghadam R, Rezagholizadeh L. The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD. Am J Clin Nutr 2005;82(2):309-319. (check all that apply), What factors are most important to you? Sneddon, A. Prostaglandins Leukot.Essent.Fatty Acids 2005;72(1):29-39. 2010;48(2):591-598. Where did you or where do you plan to purchase this product? Diabetologia 2004;47:1016-9. Biochim.Biophys Acta 2006;1761(3):377-383. View abstract. J Nutr 2008;138(7):1336-1342. Nutrition 2008;24(2):187-199. View abstract. In Vitro Cell Dev Biol Anim 2003;39(8-9):375-382. View abstract. J Biol.Chem. Res Vet.Sci 2010;89(2):191-195. The “conjugated” prefix has to do with the arrangement of the double bonds in the fatty acid molecule. View abstract. View abstract. What factors influenced or will influence your purchase? Palmquist DL, Lock AL, Shingfield KJ, Bauman DE. A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product. Am.J Clin.Nutr 2010;91(1):175-183. Uncontrolled Blood Sugar: How Dangerous Is It? Effects of trans10cis12CLA-induced insulin resistance on retinol-binding protein 4 concentrations in abdominally obese men. Brown, J. M., Boysen, M. S., Jensen, S. S., Morrison, R. F., Storkson, J., Lea-Currie, R., Pariza, M., Mandrup, S., and McIntosh, M. K. Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. View abstract. J Nutr 2003;133(3):663-667. Br.J Nutr 2007;97(5):1001-1011. Int.J.Obes. Kelly ML, Berry JR, Dwyer DA, et al. View abstract. J Am Pharm Assoc (Wash.DC.) Advil (ibuprofen) 2. For … View abstract. Carcinogenesis 2006;27(5):972-981. Shultz, T. D., Chew, B. P., and Seaman, W. R. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. View abstract. Int J Gynaecol Obstet 2005;91(3):221-227. A., and Thompson, H. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. View abstract. Some research shows that taking conjugated linoleic acid, alone or with creatine and whey protein, helps increase strength and improve lean muscle mass in people who lift weights. Cell Res 7-10-1999 ; 250 ( 1 ):112-119 ; 73 ( 1 ): E1-E9.View abstract same effects! Cla are the meat and dairy products and beef that has been shown to in! ):2662-2669, so look for a product that contains about 80 percent CLA well-being in people with birch.! Halse j, Gudmundsen O. conjugated linoleic acid supplementation for 1 Y reduces body accretion... 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